Brit (Ashley Benson), Candy (Vanessa Hudgens), Cotty (Rachel Korine), and Faith (Selena Gomez) have been best friends since grade school. They live together in a boring college dorm and are hungry for adventure. All they have to do is save enough money for spring break to get their shot at having some real fun. A serendipitous encounter with rapper "Alien" (James Franco) promises to provide the girls with all the thrill and excitement they could hope for. With the encouragement of their new friend, it soon becomes unclear how far the girls are willing to go to experience a spring break they will never forget.