Happily married couple well in there 60's who are Artie and Diane Decker(Billy Crystal and Bette Midler), are asked by there daughter Alice(Marisa Tomei) if they can watch there kids for a week, so that she and her husband(Tom Everett Scott) can go away for some alone time. Now what can start out as something simple, quickly becomes a hassle, cause they do not know there grandchildren has much has they thought.