"Restless" is the story of a boy who is restless with the living side of life and a girl, also restless with the living side of life since she just wants to get on with her own impending death. Enoch (Henry Hopper) is more interested in death since death claimed the lives of his parents and the life he once knew. Annabel (Mia Wasikowska) is a terminally ill cancer patient and instead of fighting her illness, is content living her final days studying nature. Until they met each other.