KYLE XY follows the story of Kyle, a mysterious teenage savant with the innocence of a newborn. After being found wandering in traffic and put in an institution, he meets psychologist Nicole Trager, who brings him home, much to the chagrin of her two children Lori and Josh. Even her husband Stephen is a bit wary of his wife's latest patient. As Kyle begins to show signs of brilliance, solving the mystery of his origin and potential abilities becomes the family's mission.